Visible signs
A reconstituted solution that was previously clear and has become cloudy, discoloured, or contains visible particles is the clearest sign something has changed. Any of these is a reason to stop using that vial, regardless of how long it’s been since reconstitution.
What a normal vial should look like
Freshly reconstituted retatrutide should be a clear, colourless to faintly tinted solution. Any obvious change from that baseline, compared side by side with how it looked when first mixed, is worth taking seriously.
Situational signs, even without visible changes
A vial that’s been left unrefrigerated for an extended period, exposed to direct sunlight or heat, or used well beyond its recommended reconstituted shelf life can have reduced potency even if it still looks clear. Appearance alone isn’t a reliable test for potency.
Tracking storage history
Because visible signs aren’t always present, keeping track of when a vial was reconstituted, how it’s been stored, and whether it’s had any temperature lapses is the more reliable way to judge whether it’s still good, rather than relying on how it looks in the moment.
When in doubt
If there’s meaningful uncertainty about a vial’s storage history, particularly an extended lapse in refrigeration, treating it as compromised and not using it is the more cautious approach.